Peripheral oedema in patients treated with isosorbide dinitrate.

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Randomised trial of high-dose isosorbide dinitrate plus low-dose furosemide versus high-dose furosemide plus low-dose isosorbide dinitrate in severe pulmonary oedema.

BACKGROUND Nitrates and furosemide, commonly administered in the treatment of pulmonary oedema, have not been compared in a prospective clinical trial. We compared the efficacy and safety of these drugs in a randomised trial of patients with severe pulmonary oedema and oxygen saturation below 90%. METHODS Patients presenting to mobile emergency units with signs of congestive heart failure wer...

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Evaluation of nitroglycerin in angina in patients on isosorbide dinitrate.

Seventeen male patients with angina pectoris due to coronary artery disease who had not received long-acting nitrites for at least 1 mo prior to this study were evaluated in a double-blind crossover study to investigate whether the presence of isosorbide dinitrate interfered with the effective response of exercise-induced angina to nitroglycerin administered sublingually. There was no significa...

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Comparative haemodynamic and peripheral vasodilator effects of oral and chewable isosorbide dinitrate in patients with refractory congestive cardiac failure.

venous capacitance, and calf blood flow were compared in a double-blind trial in 18 patients with refractory chronic congestive heart failure with pulmonary artery end-diastolic pressures >18 mmHg. Cardiac output and right heart pressures were measured with a Swan-Ganz thermodilution catheter, arterial pressure through an indwelling radial artery cannula, and venous capacitance and calf blood f...

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Potentiation of Isosorbide Dinitrate Effects With N-Acetlcysteine in Patients With Chronic Heart Failure

Background Supply of sulfhydryl groups with the administration of N-acetylcysteine (NAC) has been reported to reverse tolerance to nitroglycerin but not to isosorbide dinitrate (ISDN). Lack of interaction between NAC and ISDN was suggested as an explanation for these findings. The present study was therefore designed to further evaluate this hypothesis. For this purpose, we compared the hemodyn...

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CHRONIC USE OF ISOSORBIDE DINITRATE/Danahy,

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ژورنال

عنوان ژورنال: BMJ

سال: 1981

ISSN: 0959-8138,1468-5833

DOI: 10.1136/bmj.283.6303.1365-a